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High Cholesterol and Peripheral Artery Disease

High cholesterol occurs when there is an excessive amount of cholesterol, a waxy, fat-like substance, in the blood. Cholesterol is, however, necessary for building healthy cells, but too much of it can accumulate in the arteries, leading to plaque buildup. This plaque can harden over time and narrow the arteries, a condition called atherosclerosis, leading to peripheral artery disease (PAD).

One of the most common risk factors of PAD is high cholesterol. Cholesterol buildup in the arteries can lead to narrowing and blockages, limiting blood flow to the legs. Understanding the relationship between PAD and high cholesterol is important to managing and preventing this condition properly.

PAD Symptoms in High Cholesterol Patients

Patients with high cholesterol may experience symptoms of PAD earlier and have more severe symptoms due to plaque buildup. Common symptoms include:

  • Leg pain or cramping during physical activity
  • Numbness or weakness in the legs
  • Coldness in the lower foot or leg, especially when compared to the other side
  • A weak pulse or no pulse in the feet or legs
  • Hair loss or slower hair growth on the legs
  • Shiny skin on the legs

Diagnosing PAD in High Cholesterol Patients

Diagnosing PAD in individuals with high cholesterol typically involves a combination of diagnostic tests, medical history assessments, and physical examinations. Common diagnostic tests for PAD include:

  • Doppler Ultrasound: This test uses sound waves to visualize the blood flow in your arteries and detect blockages.
  • Angiogram: This imaging test involves injecting a contrast dye into the bloodstream to visualize the arteries and identify any narrowing or blockages.
  • Ankle-Brachial Index (ABI): This test compares the blood pressure in your ankle to the blood pressure in your arm to identify any reduced blood flow to the legs.

Prevention of PAD and High Cholesterol

Preventing PAD and managing high cholesterol involves making lifestyle changes and managing underlying conditions. Some preventative measures include:

  • Healthy Diet: A diet rich in fruits, vegetables, whole grains, and healthy fats (such as omega-3s) helps control cholesterol levels.
  • Regular Exercise: Physical activity for at least 30 minutes on most days can improve circulation and reduce cholesterol.
  • Quitting Smoking: Quitting smoking is one of the most effective steps to prevent PAD and cardiovascular disease.
  • Weight Management: Maintaining a healthy weight lowers cholesterol and reduces strain on the arteries.
  • Medications: Statins and other medications that lower cholesterol can help minimize plaque buildup in the arteries, lowering the risk of PAD.
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How Can High Cholesterol Lead to PAD?

High cholesterol plays a critical role in the development of PAD. Cholesterol, particularly low-density lipoprotein (LDL) or “bad” cholesterol, contributes to plaque formation on the arteries’ walls. Excess LDL cholesterol combines with fats, calcium, and other substances in the bloodstream to form plaque deposits along the inner walls of arteries. 

As plaque accumulates, the arteries narrow and stiffen, reducing the space for blood to flow through. This leads to reduced oxygen and nutrient supply to tissues, particularly in the legs. As the arteries become increasingly blocked, blood flow to the extremities is severely reduced, resulting in the classic symptoms of PAD, such as leg pain during walking (claudication) and non-healing wounds.

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What Happens When High Cholesterol and PAD Go Untreated?

Leaving PAD and high cholesterol untreated can lead to serious and potentially life-threatening complications. Without treatment, PAD tends to worsen over time. Restricted blood flow can lead to more frequent and severe symptoms, including debilitating pain and difficulty walking. In severe cases, PAD can result in critical limb ischemia, where the lack of blood flow leads to non-healing wounds, infections, and even tissue death (gangrene), which may require amputation.

High cholesterol leads to plaque buildup in arteries throughout the body, not just in the legs. Untreated high cholesterol increases the risk of heart attacks and strokes due to blockages in the arteries that supply the heart and brain. Individuals with PAD are at a significantly higher risk for these cardiovascular events.

PAD Treatments for High Cholesterol Patients

If lifestyle changes and medications haven’t worked, you may need a minimally invasive procedure to help treat PAD due to high cholesterol. American Endovascular provides various minimally invasive, image-guided PAD treatment options that help restore blood flow, prevent complications, and reduce symptoms.

  • Atherectomy: This procedure involves removing plaque from the artery using a tiny cutting device, allowing blood to flow more easily.
  • Angioplasty: During this procedure, a balloon is inflated inside the artery to widen it, improving blood flow.
  • Stent Placement: A small mesh tube, or stent, is inserted in the artery to keep it open after an angioplasty.

High Cholesterol Frequently Asked Questions

Can high cholesterol cause PAD?

Yes, high cholesterol is a major risk factor for PAD. It adds to plaque buildup in the arteries, leading to narrowing and blockages that limit blood flow.

How long does it take for PAD to develop with high cholesterol?

It varies from person to person and depends on lifestyle, genetics, and overall health. People with long-term, unmanaged high cholesterol, however, are at greater risk of developing PAD earlier in life.

What is the best way to manage high cholesterol and prevent PAD?

The most effective way to prevent PAD is to manage high cholesterol through a mix of regular exercise, a healthy diet, and medications.

Vascular Specialists in NY

At American Endovascular, we specialize in treating PAD with minimally invasive procedures. Our team of vascular specialists offers comprehensive care, from risk factor evaluation to advanced treatment options. Find one of our vascular specialists in New York.

Vascular Centers in New York

We operate several vascular centers in New York, providing advanced treatments for PAD. Our convenient locations ensure that you have expert care close to home.

Brooklyn, NY
71 Carroll Street
Brooklyn, NY 11231
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Harlem, NY
505 East 116th Street,
2nd Floor
Harlem, NY 10029
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Queens, NY
30-30 Northern Blvd
Suite 501
Queens, NY 11101
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What Our Patients Are Saying

When came in to see Dr. Shams I was in alot of pain in my legs. He took care of my needs immediately. After the procedure which went well. The pain in my legs had diminished greatly . Dr Shams is patient and understanding. He is a great doctor. The staff was pleasant. The nurses were amazing especially one that was having a baby she was very nice to me and took care of my needs ❤️.
Betty Branch
Betty Branch
00:39 01 Aug 26
These Doctor’s That Works At Harlem Endovascular, What These People Had Did To My Legs, They Did A Real Great Job, And They Really Are The Best !!!
Raul Diaz
Raul Diaz
18:47 21 Jul 26
Excellent staff & Dr and his assistants
Emily
Emily
21:32 25 Jun 26
I was so confident in them the nurses and the receptionist are also kind and caring about you. The Dr and his assistant were excellent. Everyone in that office was excellent. I felt very comfortable with them.
Emily Fanelli
Emily Fanelli
21:31 25 Jun 26
Awesome service, a beautiful staff and teamFrom booking ur appointment to receiving care. Had i known about them i know I would have been better already. I love how polite understanding and comfortable everyone make you feel it definitely make you feel better during care The services here are top notch. I know my healing journey is even greater.
Barbara Maschack
Barbara Maschack
21:31 18 Jun 26
Dr Sham is a very good doctor who helped me with everything he made sure he had they gave me something for the pain and to relax before the procedure and everything went perfect he is the best 5 star’s.
Martin Fagen
Martin Fagen
20:42 15 Jun 26
His team is excellent. Make you feel safe.
Doris Val
Doris Val
22:41 02 Jun 26
Everyone was friendly and helpful and Dr. Rivera was very focused in doing what is best for my mother.
Michael Robayo
Michael Robayo
21:15 02 Jun 26
Very good staff and doctor.
Moises Cuevas
Moises Cuevas
20:57 28 May 26
Very professional. Kept me informed through the procedure.
Laurence Clarke
Laurence Clarke
20:37 27 May 26
Great Service, they explain everything and make you feel relaxed comfortable. From the staff to the Doctor fabulous!
Janet “Jangirl212”
Janet “Jangirl212”
20:49 20 May 26
It’s been the 2nd time I have the procedure no complaint at all
fernando medina
fernando medina
13:03 20 May 26
Just wonderful!!!
Rose Grandma
Rose Grandma
23:05 14 May 26
Doctor shams and his team are very good .They took care of me and showed me that they cared how I was feeling after the procedure .i highly recommended the doctor and his staff
Maria Ortiz
Maria Ortiz
20:34 05 May 26
Dr. Shams has done 2 procedures in my left leg and had cero issues. He did a great job both times.
Roberto Rosales
Roberto Rosales
20:26 04 May 26
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